Skrining Berbagai Jenis Surfaktan Dan Kosurfaktan Sebagai Dasar Pemilihan Formulasi Nanoemulsi

Authors

  • Ni Luh Putu Karunia Vidya Nirmalayanti Universitas Udayana

DOI:

https://doi.org/10.37329/metta.v1i3.1552

Keywords:

Nanoemulsion, Screening, Cosurfactant, Surfactant, Pseudoternary

Abstract

The main components for making nanoemulsions are oil, surfactants, and cosurfactants. Before formulating nanoemulsions, screening the surfactants and cosurfactants is necessary to produce an optimum formula. Thus, it carries out surfactants screening, namely (tween 20, tween 60, tween 80) and cosurfactants (propyleneglycol, PEG 400, glycerin). This study aimed to screen suitable selection and cosurfactants as the basis for making nanoemulsions. Then, the research method was carried out in two ways: surfactant screening and cosurfactant screening. The final results were analyzed using a pseudoternary phase diagram. The surfactant screening results were tween 20 (40mL), tween 60 (40mL), tween 80 (60mL); thereby, the best surfactant candidate was tween 80. The results of the surfactant screening on the pseudoternary phase diagram are the most optimal, namely tween 80 with propylene glycol because it has a large nanoemulsion formation area. The study proposed the ratio of oil: smix (tween 80 and propyleneglycol) (1:9) as the optimum formula used to make a nanoemulsion base.

References

Ansel, H. C., Allen, L. V., and Popovich, N.G. (2005). Pharmaceuticals Dosage Forms and Drug Delivery System. Lippincott Williams dan Willems. Philadelphia.

Attwood, D. Microemulsions. (1994). In: Kreuer J, Ed. Colloidal Drug Delivery Systems. Marcel Dekker. New York. Hal 31-71.

Eichner A., Stahlberg S., Sonnenberger S., Lange S., Dobner B., Ostermann A., et al. (2017). Influence of The Penetration Enhancer Isopropyl Myristate on Stratum Corneum Lipid Model Membranes Revealed by Neutron Diffraction and 2H NMR Experiments. Biochimica et Biophysica Acta (BBA)-Biomembranes. 1859(5):745-755.

Herbianto, A. S. (2018). Pengaruh Perbedaan Konsentrasi Surfaktan terhadap Karakter Fisik dan pH Nanoemulsi Pencerah Kulit. CALYPTRA. 7(1):736-746.

Hussain, A., Shakeel, F., Singh, S. K., Alsarra, I. A., Faruk, A., Alanazi, F. K., and Christoper, G. P. (2019). Solidified SNEDDS for The Oral Delivery of Rifampicin: Evaluation, proof of Concept, in vivo Kinetics, and in Silico GastroPlusTM simulation. International journal of pharmaceutics, 566, 203-217.

Kakoty M., Gogoi S.B. (2018). Evaluation of Surfactant Formulation for EOR in Some Depleted Oil Felds of Upper Assam. In: Sustainability Issues in Environmental Geotechnics, Springer Nature. Proceedings of the 2nd GeoMEast: International Congress and Exhibition. 57-75.

Listyorini, N. M. D., Wijayanti, N. L. P. D., dan Astuti, K. W. (2018). Optimasi Pembuatan Nanoemulsi Virgin Coconut Oil. Jurnal Kimia. 12(1): 8-12.

Martin, A., Swabrick, J ., and Cammarata, A. (1993). Farmasi Fisika. Edisi III. Jakarta: UI-Press.

Ng, K. W. (2018). Penetration Enhancement of Topical Formulations. Pharmaceutics. 10(2):51.

Nurfauziah, R., dan Rusdiana, T. (2018). Formulasi Nanoemulsi Untuk Meningkatkan Kelarutan Obat Lipofilik : Article Review. Farmaka. 16(1):352-360.

Nurpermatasari, A., dan Ernoviya, E. (2020). Formulasi dan Evaluasi Nanoemulsi Ketokonazole. Jurnal Dunia Farmasi. 4(3):138-148.

Priya, S., Koland, M., and Suchetha Kumari N. (2015). Nanoemulsion Components Screening Of Quetiapine Fumarate: Effect Of Surfactant And Co Surfactant. Asian Journal of Pharmaceutical and Clinical Research. 8(6):136-140.

Rismarika., Indri, M., Yusnelti. (2020). Pengaruh konsentrasi PEG 400 Sebagai Kosurfaktan Pada Formulasi Nanoemulsi Minyak Kepayang. Chempublish. 5(1):1-14.

Rowe, R.C., Sheskey, P. J., and Quinn, M. E. 2009. Handbook Of Pharmaceutical Excipients, 6th Edition. London: The Pharmaceutical Press.

Saifullah, M., Ahsan, A., and Shishir, M.R.I. (2016). Production, Stability and Application of Micro and Nanoemulsion in Food Production and The Food Processing Industry, In Emulsions. Cambridge USA: Academic Press.

Sarmah, S., Subrata B.G., Fan, X., and Annanya A.B. (2019). Characterization and Identifcation of The Most Appropriate Nonionic Surfactant For Enhanced Oil Recovery. Journal of Petroleum Exploration and Production Technology. 10(1):115-123.

Silva, H. D., Cerqueira, M. A., Souza, B. W., Ribeiro, C., Avides, M. C., Quintas, M. A., Coimbra, J. S. R., Carneiro-da-Cunha, M. W., and Vicente, A. A. (2011). Nanoemulsions of B-Carotene Using a High Energy Emulsification Evaporation Technique. Journal Of Food Engineering, 102:130-135.

Syaputri, F. N., dan Patricia, V. M. (2019). Pengaruh Penambahan Emulgator Tween Dan Span Terhadap Stabilitas Krim. Journal of Science, Technology and Entrepreneur. 1(2):140-146.

Vatsraj, S., Chauhan, K., and Pathak, H. (2014). Formulation of a Novel Nanoemulsion System for Enhanced Solubility of a Sparingly Water Soluble Antibiotic, Clarithromycin. Journal of Nanoscience. 1-7.

Villar, A. M. S., Naveros, B. C., Campmany, A. C. C., Trenchs, M. A., Rocabert, C. B., and Bellowa, L. H. (2012). Design and Optimization of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) for Enhanced Dissolution of Gemfibrozil. International Journal of Pharmaceutics. 431(1-2):161-175.

Yusuf, N. A., dan Fatmawaty, A. (2017). Pengaruh Isopropil Mirisrat Sebagai Bahan Peningkat Penetrasi Terhadap Laju Difusi Krim Pemutih Ekstrak Etanol Daun Murbei (Morus alba L). Jurnal Ilmiah Manuntung. 3(1):43-51.

Downloads

Published

28-12-2021

How to Cite

Nirmalayanti, N. L. P. K. V. (2021). Skrining Berbagai Jenis Surfaktan Dan Kosurfaktan Sebagai Dasar Pemilihan Formulasi Nanoemulsi . Metta : Jurnal Ilmu Multidisiplin, 1(3), 158–166. https://doi.org/10.37329/metta.v1i3.1552

Issue

Section

Articles